Having already slain the apparently invincible Barcelona, giant killers Espanyol now turn their attention to Real Madrid who have reduced the gap at the top of the table to seven points with a nine match winning run in the league.
Arsene Wenger is desperate to see his Arsenal side start translating their European form into a sustained Premier League challenge.
Guus Hiddink´s insistence that his Chelsea side have no margin for error if they are to salvage something from a chaotic season will once again provide a challenging benchmark as Wigan Athletic visit Stamford Bridge this weekend.
After a memorable night in the heady surroundings of the Bernabeu in midweek it is back to basics for Liverpool on Saturday as they travel to Middlesbrough on a quest to get their Premier League challenge back on track.
Besiktas remain near the top of the Turkish Super Lig following a 2-1 victory over Istanbul BB in a local derby on Friday.
Benfica re-applied pressure on Portuguese leaders FC Porto, beating Leixoes Matosinhos 2-1 in Friday’s only league game.